Braves retire Chipper Jones' No. 10 jersey

By GEORGE HENRY

Associated Press

Associated Press Sports

updated 7:18 p.m. ET June 28, 2013

ATLANTA (AP) - Chipper Jones has been greeted with a long ovation as the Atlanta Braves retired his No. 10 jersey Friday night.

Jones, the 1999 NL MVP and an eight-time All-Star, was honored before Atlanta's game against Arizona. The former third baseman retired after last season's playoff loss to St. Louis having played his entire 19-year career with the Braves.

Wearing a gray suit and a red tie, Jones spoke to the Turner Field crowd before he threw out the ceremonial first pitch and was driven around the field to adoring cheers.

Most seats in the stands were filled as Jones stepped to the microphone while "Crazy Train," the 1980 hit single by Ozzy Osbourne that used to play before his at-bats, boomed through the public address system.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Advising Underprepared Students - The Mentor

Advising Underprepared Students

Craig M. McGill, Florida International University

The building blocks of most professions are theory and practice. Continual practice over the course of time can certainly help a professional become more adept in his or her work, but it almost certainly can be strengthened with a practice rooted in theory. Because academic advisers must accommodate students from all walks of life, one theory or even one set of theories cannot suffice.?In fact, attempting to use one theory is not only inadequate but could be hazardous and irresponsible. Hagen and Jordan (2008) stated, ?Advisers have license to draw upon a wide array of theoretical perspectives, because they have come to advising not from one field, but from many; they have the obligation to resist adopting only one theoretical perspective because the phenomenon of academic advising is so very complex? (p. 32).

This article presents a scenario focusing on potential issues when working with an underprepared student. Though the article will reference many theories, it will not include an overview of the theories themselves. Rather, the adviser is encouraged to use the information below as a starting point and explore the literature.

Scenario

Joe is a 19-year-old, first-generation, underprepared, undecided student. He is from a small town in the western part of his state where the population is sparse. No one in his family has gone to college before, and they do not feel a college education is necessary. Joe?s parents were hoping he would marry a nice girl from the area and take over the family farm someday. Joe does not know what interests him, but he knows that he does not want to farm for the rest of his life. His folks let him go to college, and they try to be supportive; but because they feel they have been successful without a college degree, they do not really value a formal college education. Additionally, Joe realizes he has not been exposed to many different types of people or ideas in his small hometown of three hundred residents.

Joe is in his first semester of college. By all appearances, he seems kind, responsible, and intelligent, but he does not have the same strong, educational background that many of his peers do and, thus, he is entering college with many academic deficiencies. Consequently, he is insecure, nervous, and doubtful about his chances of succeeding. Joe?s adviser knows that he is an at-risk student who will need extra attention and therefore asks a lot of questions to get a good sense of Joe and, in the process, establishes a positive rapport with him. The adviser knows that this bond is important if Joe is to succeed in a world far different than anything he has ever known. After a few appointments with Joe and several rounds of questions, Joe?s adviser is trying understand out what brought him to a large college, so far away from home when he is underprepared (and only conditionally accepted into the college) with no developed educational or career goals. After Joe?s adviser asks the question very tactfully, Joe admits that the only reasons he chose to go to college were to get out of the town in which he grew up and to do something other than farming.

Theoretical Application

From a student development standpoint, most of Joe?s challenges come from his underpreparedness. Underprepared students generally display one or more of the following characteristics: ?low academic self-concept, unrealistic grade and career expectations, unfocused career objectives, extrinsic motivation, external locus of control, low self efficacy, inadequate study skills for college success, a belief that learning is memorizing, and a history of passive learning? (Ender & Wilkie, 2000, pp. 134?135). Joe definitely has a low academic self-concept, and it is probable that his personal self-concept in general is fairly undeveloped. The only thing Joe knows at this point is that he is using college as an escape from the farm and farm life. Going to college to escape life is a typical trait of first-generation students (Sickles, 2004).

Joe?s underpreparedness likely contributes to his?considering what he might do for a living has never really occurred to him, as the family expectation was for him to take over the farm. Being a first-generation student also complicates Joe?s situation. According to Riehl (1994), ?first-generation college students do not have the benefit of parental experience to guide them, either in preparing for college or in helping them understand what will be expected of them after they enroll? (p. 16). Because nobody in his family has been to college, they are unable to help Joe navigate the college system or even comprehend the struggles and challenges that he faces.

Thus, the adviser?s role becomes even more pivotal in the education of an underprepared student. Joe does not know how to ?do? college, so even the little things that seem trivial for most students should be discussed with him. Joe?s adviser should emphasize ?regular class attendance, ways to be an active learner, how expectations and requirements differ in high school and college, and ways in which the student may participate in class more actively? (Ender & Wilkie, 2000, p. 137). Joe?s adviser must take a developmental approach and teach him skills to succeed. As Miller and Murray (2005) pointed out, ?academically underprepared students often have no idea how to go about earning a degree: They do not know what steps they must take or the particulars of what institutions expect of them. It is imperative that advisers outline both the institution?s expectations of students and what students can expect from advisers throughout their academic careers? (p. 2).

Even basic life skills likely fall within an academic adviser?s scope of teaching when working with underprepared students. An adviser must help students to ?develop cognitive maturity, integrated identity, and mature relationships to become effective citizens? (Hunter & Kendall, 2008, pg. 143). If this is accomplished, students are more apt to become involved in the advising process and, thus, take control of and responsibility for their educational destinies. Hunter and Kendall (2008) stated, ?The quality of education a student receives is directly related to the student?s involvement with his or her academic experience? (p. 143).

Establishing a rapport with academically underprepared students is critical to their success; therefore, Joe?s adviser should learn as much as possible about him during their introductory meetings. Because Joe does not have a clear sense of what he wants to do, what interests him, or, ultimately, what is even possible, Joe?s adviser must know what questions to ask. Getting to know the student and allowing him or her to gain a sense of you will help to establish this rapport. While the adviser-advisee relationship is important in ensuring that every student succeeds, it is especially true for the underprepared student. Steele and McDonald (2008) noted, ?Spending time getting to know our students not only in terms of their academic and career interests but also in terms of their backgrounds and personal experiences is a key component to working with students as they move through the college experience? (p. 157). As unsure as these students are likely to be of themselves, they must acquire this important boost of self-esteem and the confidence of their academic advisers.

When working with Joe, it is very important to help him discover what he loves and what he might be interested in doing and cater to his talents and strengths. Miller and Murray (2005) suggested that a strengths-based approach can be very helpful in retaining underprepared students. In working with underprepared students Steele (1999) argued that the phrase ?you need remedial work? should be replaced with ?you may be somewhat behind at this time but you are a talented person. We can help you advance at an accelerated rate? (p. 23). Focusing on what Joe has to offer as opposed to what is missing can be crucial to his success.

Another approach that may help Joe explore what interests him is applying Appreciative Advising, the ?intentional collaborative practice of asking positive, open-ended questions that help students optimize their educational experiences and achieve their dreams, goals, and potentials? (Amundsen, Bloom, & Hutson, 2006). Rooted in positive psychology, the advising model approaches life as a series of opportunities rather than a series of problems (Bloom, Hutson, & He, 2008). By working through the six stages of Appreciative Advising?disarm, discover, dream, design, deliver, and don?t settle?the adviser can help Joe choose courses that interest him and encourage him to journal about what excites him.

In the beginning, Joe might even turn to advisers for simple day-to-day matters. An effective adviser might encourage Joe to contact him or her much of what he may need in the beginning. But as time goes on, Joe should gain more self-reliance, and the advising relationship ?? as it develops, encourages student independence as they achieve educational, career, and personal goals through the use of the full range of institutional and community resources? (Miller & Murray, 2005).

Joe is a person with sound, positive values and who simply needs a chance. Many of his professors will tend to view him the same way they view other students and not make themselves available for the extra support that he will need to succeed. The academic adviser can play a pivotal role in his success by establishing and maintaining a relationship that is ?ongoing and purposeful, challenging for the student but also supportive, goal oriented, and intentional? (Ender & Wilkie, 2000, p. 141). Underprepared students can certainly succeed; they just need more guidance along the way.

Conclusion

In the practice of academic advising, it is important to remember that an adviser may be the most important campus contact for a student. Bultman, Vowell, Harney, Smarrelli, and Ames (2008) noted that advisers can help students make??sense out of the curriculum ? to see its interconnections and the potential development of important skill sets that will serve students for an entire lifetime? (p. 418).?The opportunities advising presents include?engagement, developing critical thinking and reflection skills, forging connections so that coursework does not seem like an endless stream of unrelated classes, and discussion of vocation ? and ultimately, helping students to figure out how they want to live their lives. Considering the spectrum of students that advisers see, it is important that they are equipped with theory to aid in the challenging but important work that they do. Theory should continue to be developed and incorporated into both academic advising literature and practice. In terms of discovering new ways of integrating theories from other disciplines into advising practice and devising others unique to the field, some of the most interesting work is yet to come.

References

Amundsen, S. A., Bloom, J. L., & Hutson, B. L. (2006). Appreciative Advising Interest Group meeting. NACADA Annual Conference. Indianapolis, IN.

Bloom, J. L., Hutson, B. L., & He, D. Y. (2008).?The appreciative advising revolution. Champaign, IL: Stipes.

Bultman, J. E., Vowell, F. N., Harney, J. Y., Smarrelli, J., & Ames, S. (2008). Campus administrator perspectives on advising. In V. N. Gordon, W. R. Habley, and T. J. Grites (Eds.) Academic advising: A comprehensive handbook (2nd ed.), (pp. 415?437). San Francisco, CA: Jossey-Bass.

Ender, S. C. & Wilkie, C. J. (2000). Advising students with special needs. In V. N. Gordon & W. R. Habley (Eds.), Academic advising: A comprehensive handbook (pp. 118?143). San Francisco, CA: Jossey-Bass.

Hagen, P. L., & Jordan, P. (2008). Theoretical foundations of academic advising. In V. N. Gordon, W. R. Habley, & T. J. Grites (Eds.), Academic advising: A comprehensive handbook (2nd ed.), (pp. 17?35). San Francisco, CA: Jossey-Bass.

Hunter, M. S., & Kendall, L. (2008). Moving into college. In V. N. Gordon, W. R. Habley, T. J. Grites, & Associates (Eds.), Academic advising: A comprehensive handbook (pp. 142?156). San Francisco, CA: Jossey-Bass.

Miller, M. A., & Murray, C. (2005). Advising academically underprepared students. NACADA Clearinghouse of Academic Advising Resources. Retrieved from http://www.nacada.ksu.edu/Resources/Clearinghouse/View-Articles/Academically-underprepared-students.aspx

Riehl, R. J. (1994). The academic preparation, aspirations, and first-year performance of first-generation students. College and University, 70, pp.14?19.

Sickles, A. R. (2004). Advising first-generation students. NACADA Clearinghouse of Academic Advising Resources. Retrieved from http://www.nacada.ksu.edu/Resources/Clearinghouse/View-Articles/First-generation-students.aspx

Steele, C. M. (1999). Race and the schooling of black Americans. In M. H. Davis (Ed.), Social Psychology: Annual Editions. Guilford, CT: Duskin/McGraw-Hill.

Steele, G. E., & McDonald, M. L. (2008). Moving through college. In V. N. Gordon, W. R. Habley, & T. J. Grites, (Eds.), Academic advising: A comprehensive handbook (2nd ed.) (pp. 157?177). San Francisco, CA: Jossey-Bass.

About the Author(s)

Craig M. McGill, Florida International University

Craig M. McGill, M.M., M.S., is an academic adviser in the Department of English at Florida International University in Miami, Florida. He can be reached at cmmcgill@fiu.edu.

Filed Under: advising, students, underprepared

Source: http://dus.psu.edu/mentor/2013/06/advising-underprepared-students/

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Senate passes immigration bill

WASHINGTON (AP) ? The Senate has passed historic immigration legislation offering the hope of American citizenship to millions, while promising a military-style surge to secure the border.

The vote was 68-32, far more than the majority needed to send the measure to the House. Prospects there are not nearly as good and many conservatives are opposed.

Vice President Joe Biden presided, and senators cast their votes from their desks, both steps reserved for momentous votes.

The bill, a priority for President Barack Obama, would amount to the most sweeping changes in decades to the nation's immigration laws.

Source: http://news.yahoo.com/senate-passes-immigration-bill-203027013.html

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Can You Be Addicted To Carbs? Scientists Are Checking That Out

Eating refined carbohydrates like bagels may stimulate brain regions involved in reward and cravings, research suggests.

iStockphoto.com

Eating refined carbohydrates like bagels may stimulate brain regions involved in reward and cravings, research suggests.

iStockphoto.com

Fresh research adds weight to the notion that certain foods (think empty carbs like bagels and sweet treats) can lead to more intense hunger and overeating.

Fast-digesting carbohydrates can stimulate regions of the brain involved in cravings and addiction, according to a study published in the American Journal of Clinical Nutrition.

Prior studies have shown that highly desirable foods, perhaps a cheesecake or pie, can trigger pleasure centers in the brain. But what's new about this research is that it shows that even when people are unaware of what they're eating, the intake of fast-digesting carbs can activate parts of the brain associated with pleasure, reward and addiction.

To evaluate this, Dr. David Ludwig, director of the obesity prevention center at Boston Children's Hospital, and his colleagues conducted brain scans in 12 overweight men after they consumed two different kinds of test milkshakes.

Both milkshakes had the same number of calories and similar ingredients, but one contained more fast-digesting carbs and the other was made of slower-digesting carbohydrates. The concept here is that so-called high-glycemic index foods such as sugar and highly processed breads move through the body faster than low-glycemic index foods such as fruit and whole grains.

After the participants drank the rapidly digesting carb shake, their blood sugar spiked and then crashed four hours later. And it's at this point that researchers documented activation of a part of the brain called the nucleus accumbens, a small area that is involved in emotions and addiction. Ludwig told The Salt: "The scans showed intense activation in brain regions involved in addictive behavior."

The idea that certain foods may be addictive is controversial. Some scientists think it's overstating the matter. And clearly it's not settled as to whether activity in these brain regions would be seen widely in the population, or perhaps only among those who are overweight or prone to overeating.

As Dr. Robert Lustig, a professor of clinical pediatrics at the University of California, San Francisco, points out, this research can't tell us if there's a cause and effect relationship between eating certain foods and triggering brain responses, or if those responses lead to overeating and obesity.

"[The study] doesn't tell you if this is the reason they got obese," says Lustig, "or if this is what happens once you're already obese."

Nonetheless, Lustig told The Salt that he thinks this study offers another bit of evidence that "this phenomenon is real." He has been a leading voice in suggesting that sugar is the cause of obesity and other health problems.

Increasingly, the concept of food addiction is gaining attention from researchers. There's a body of work exploring the connection, says Nicole Avena, a neuroscientist at the University of Florida who studies food and the brain.

This study, she says, adds to the growing literature that suggests that high-sugar foods can affect the brain "in ways that can alter reward processing and potentially fuel overeating."

Source: http://www.npr.org/blogs/thesalt/2013/06/26/195292850/can-you-be-addicted-to-carbs-scientists-are-checking-that-out?ft=1&f=1007

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J&J in $1 billion deal to bolster prostate-cancer focus

By Ransdell Pierson

(Reuters) - Johnson & Johnson said it would pay up to $1 billion for Aragon Pharmaceuticals and its experimental drugs for prostate cancer, to bolster J&J's role in the field after it acquired another experimental prostate-cancer treatment four years ago that has become a leading brand.

J&J on Monday said Aragon's lead product, called ARN-509, has potential to help patients whose prostate cancer has not yet spread to other parts of the body, as well as patients whose cancer has spread.

By contrast, J&J's blockbuster Zytiga treatment, acquired through its $1 billion purchase of Cougar Biotechnology in 2009, was approved in 2011 only for patients whose cancer has already spread.

Moreover, although Zytiga has become a blockbuster only two years after being launched, it could face competition from cheaper generics by 2016 in the United States, while ARN-509 will have U.S. marketing exclusivity until 2028, Leerink Swann analyst Danielle Antalffy said in a research note.

"We expect that J&J will be able to accelerate ARN-509's development timeline and expand the depth of clinical programs in order to reach the market ahead of Zytiga's U.S. patent expiration," Antalffy said.

Zytiga and ARN-509 are both meant for patients who fail to benefit from treatments that block testosterone, the male hormone that fuels prostate cancer. But the two drugs work differently.

ARN-509 has potential to be the most effective treatment for such patients, Antalffy said.

J&J spokeswoman Kellie McLaughlin said late-stage trials will be needed to assess how ARN-509 would be used. But she said the drug and Zytiga potentially could work well when used in combination because of their slightly different mechanisms of action.

"They might also be studied to see if they can be used sequentially, with patients first taking ARN-509 and then moving on to Zytiga as their disease progresses," McLaughlin said.

ARN-509, which belongs to a new class of drugs called androgen receptor signaling inhibitors, works in a similar way to Medivation Inc's already approved Xtandi treatment. But Antalffy said early clinical data suggest ARN-509 has potential to be more potent, and to sidestep seizure risks seen with the Medivation drug.

Aragon will receive $650 million in cash upfront from J&J under the deal, and a possible second payment of $350 million if ARN-509 meets certain milestones.

The deal does not include development of Aragon's treatment for breast cancer, which will be spun off into a separate company called Seragon Pharmaceuticals ahead of the deal and will be run by Aragon's chief executive officer.

McLaughlin said Zytiga has had the most successful introduction of any oral treatment for cancer, having been used by more than 60,000 patients worldwide. It generated first quarter sales of $344 million, putting it on track toward full-year sales well above the $1 billion J&J paid for Cougar Biotechnology.

"Prostate cancer is a key area of focus for us, and we are really excited about ARN-509 and adding it to our portfolio," McLaughlin said.

Shares of J&J closed up 0.8 percent to $85.63 on the New York Stock Exchange, outpacing a 0.3 percent gain for the ARCA Pharmaceutical Index of large U.S. and European drugmakers.

(Reporting by Ransdell Pierson and Caroline Humer; Editing by Gerald E. McCormick, Sofina Mirza-Reid and Bob Burgdorfer)

Source: http://news.yahoo.com/j-j-1-billion-deal-bolster-prostate-cancer-164827529.html

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Windows 8.1 in-depth hands-on: features, apps, impressions and screenshots

The last time we wrote about Windows 8.1, we had lots to talk about, but very little to share in the way of hands-on impressions. You see, though Microsoft unveiled loads of new features, apps and UI tweaks, it only released a handful of screenshots -- and nobody outside the company was permitted to actually use the new software. Today, though, the OS update is available for anyone to download for free; in fact, because we're oh-so special, we've playing around with it for about 15 hours already. So while that's not enough time to put together a comprehensive review, we feel qualified to offer a few early thoughts. If you're curious, you can meet us after the break for impressions on everything from the new panorama capture feature to Xbox Radio. And yes, we brought screenshots this time. Lots of 'em.

Filed under: Software, Microsoft

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White House: US respects Iran election results

WASHINGTON (AP) ? Offering praise for Iranians and reproaching their government, the Obama administration said Saturday it respected the results of a presidential election conducted under restrictive conditions.

Shortly after moderate cleric Hasan Rowhani was declared the winner, White House spokesman Jay Carney said the U.S. congratulated Iranians for their courage in voting. He said Iranians were determined to make their voices heard despite the limitations the ruling government imposed on the political process.

The election "took place against the backdrop of a lack of transparency, censorship of the media, Internet, and text messages, and an intimidating security environment that limited freedom of expression and assembly," Carney said in a statement. He added that despite those obstacles, "the Iranian people were determined to act to shape their future."

Secretary of State John Kerry also lauded the Iranian people and added: "President-elect Rowhani pledged repeatedly during his campaign to restore and expand freedoms for all Iranians. In the months ahead, he has the opportunity to keep his promises to the Iranian people."

The stunning surge in Friday's election behind Rowhani, a former nuclear negotiator, was perceived by supporters as a rebuke to hard-line policies that have left Iran diplomatically and economically isolated. The U.S. and other nations have used penalties to undercut Tehran's disputed nuclear program.

Iran's ruling clerics barred more prominent reform candidates from the ballot, leaving a group of mostly staunch loyalists to the Islamic establishment. Iran's opposition settled on Rowhani as the least objectionable, making the 64-year-old cleric the de facto candidate for reform-minded Iranians.

"It is our hope that the Iranian government will heed the will of the Iranian people and make responsible choices that create a better future for all Iranians," Carney said. Signaling that the election has not changed the administration's stance, Carney said the U.S. is still willing to engage Tehran directly to find a diplomatic solution to concerns about Iran's nuclear program.

The U.S. has been ramping up efforts geared toward persuading Iran to prove its nuclear program is peaceful. The U.S. believes Iran is working to develop nuclear weapons, a charge that Iran denies.

But the strict limitations the regime placed on who could compete in the election dampened U.S. hopes that a postelection Iran would pursue a different course. Kerry said last month he wasn't optimistic that the election would produce any change in Iran's nuclear ambitions, a topic he revisited in his statement after the election.

"We, along with our international partners, remain ready to engage directly with the Iranian government," Kerry said. "We hope they will honor their international obligations to the rest of the world in order to reach a diplomatic solution that will fully address the international community's concerns about Iran's nuclear program."

Source: http://news.yahoo.com/white-house-us-respects-iran-election-results-190857699.html

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Bucs blank Dodgers, gain game on first place

By WILL GRAVES

AP Sports Writer

Associated Press Sports

updated 10:47 p.m. ET June 14, 2013

PITTSBURGH (AP) - Jeff Locke barely made the Pittsburgh Pirates starting rotation out of spring training, winning a battle with Kyle McPherson almost by default after McPherson struggled and a better option never materialized.

"You know when you break camp as the No. 5 guy, if something happens or if someone starts off hot down below you might be the guy that gets moved," Locke said. "It's kind of pitching to survive."

Something that's no longer an issue for him as the de facto ace for the injury ravaged Pirates.

The 25-year-old, who looks a couple days removed from high school, allowed two hits over seven innings as the Pirates silenced the Los Angeles Dodgers 3-0 on Friday night. Locke struck out five and walked one while needing just 75 pitches to get 21 outs.

Locke (6-1) barely resembled the guy who walked seven Chicago Cubs in his previous start, keeping the Dodgers off balance by working both sides of the plate and not being afraid of letting his defense do the rest as his ERA dropped to 2.19.

"He came to pitch," Pittsburgh manager Clint Hurdle said. "Just very, very efficient. He made pitches the entire seven innings."

Jason Grilli worked out of a two-on, no-out jam in the ninth for his National League-leading 24th save. Andrew McCutchen hit a two-run double in the third inning off Stephen Fife (1-2) and gave the Pirates some insurance when he scored on a sacrifice fly by Neil Walker in the ninth.

The story, however, remains the soft-spoken left-hander from New Hampshire. Locke lost his first game of the year, a 6-2 defeat in Los Angeles on April 10. He hasn't been beaten since and appears to be growing stronger each time he takes the hill, a welcome development for a starting rotation in tatters.

A.J. Burnett, Wandy Rodriguez, James McDonald and Jeanmar Gomez all are on the disabled list, leaving Locke and veteran Francisco Liriano as the top-end starters for one of baseball's biggest first-half surprises.

If the spotlight is getting to Locke, it doesn't show.

"I wouldn't say (my) comfort level has changed at all," Locke said. "It's still uncomfortable. The confidence is definitely there. That's something I've gained into spring training and I've been able to carry it through the first half of the season so far."

Los Angeles didn't get a runner to second base while Locke was in the game, but had chances late to tie the game.

Pittsburgh reliever Mark Melancon struck out pinch-hitter Juan Uribe with runners in scoring position in the eighth. Yaisel Puig and Nick Punto hit consecutive singles off Grilli to start the ninth.

Grilli then retired Adrian Gonzalez, Hanley Ramirez and Mark Ellis to remain a perfect 24 for 24 in save opportunities.

"He threw eight pitches in that at-bat," Gonzalez said. "When I see eight pitches, I shouldn't strike out. I needed to put a ball in play and I should have. That was bad hitting on my part."

Something that's going around for Los Angeles, which has dropped five of six and is now a season-low 10 games under .500 (28-38).

The Dodgers played without manager Don Mattingly, who served a one-game suspension for his role in the brawl with Arizona earlier in the week. Bench coach Trey Hillman filled in and watched his team get handcuffed by a player who is making $497,500. The average salary on the Dodgers is nearly $10 million.

"(Locke) commanded three pitches pretty well and he pitched in a lot," Hillman said. "The fastball and the changeup were good and he kept us honest with the breaking ball all night."

McCutchen gave the Pirates all the offense they would need when he doubled to the corner in right field in the third, scoring Alex Presley and Russell Martin. Fife, making just his fourth start of the season, settled down and escaped without further damage when McCutchen was gunned down at home trying to score on a ground ball and Clint Barmes flew out to left with the bases loaded later in the inning.

Fife gave up six hits in five innings, walking three and striking out four.

"It was a battle the whole time I was in there," Fife said. "I just couldn't get that easy inning."

That wasn't a problem for Locke, who felt fresh after heading to the dugout in the middle of the seventh. He didn't put up any fight to stay in the game, not with the one-two punch of Melancon and Grilli available.

It almost backfired. Andre Ethier singled with one out in the eighth and Jerry Hairston Jr. doubled to the gap in left-center one batter later. Ethier held up at third rather than try to score, and it cost the Dodgers when pinch-hitter Juan Uribe struck out.

Pittsburgh added an insurance run when McCutchen singled leading off the bottom of the eighth and later scored on a sacrifice fly by Neil Walker.

Grilli made it stand up against the meat of Los Angeles' lineup.

NOTES: Locke singled off Fife in the third to end an 0-for-30 skid dating to last season ... Dodgers catcher A.J. Ellis went 0 for 3 with 3 strikeouts in his return from the disabled list. He also threw out two would-be base stealers. Ellis missed 14 games with a strained oblique. To make room for Ellis, Los Angeles designated C Ramon Hernandez for assignment. Hernandez hit .208 with three homers and six RBIs in 17 games with the Dodgers ... The series continues on Saturday when rookie Brandon Cumpton makes his major league debut for the Pirates, replacing Burnett. Clayton Kershaw (5-4, 1.88 ERA) starts for Los Angeles ... Dodgers reliever J.P. Howell pitched two perfect innings in relief. Howell is appealing a two-game suspension for his role in the brawl with the Diamondbacks. Reliever Ronald Belisario sat out to serve his one-game suspension.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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The Doubles King

HBT: Manny Machado is on pace to shatter the all-time single-season doubles mark. His?two two-baggers Friday put him on a list with only Joe DiMaggio and Ted Williams.

Mike Mcginnis / Getty Images

Source: http://nbcsports.msnbc.com/id/52212024/ns/sports-baseball/

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Six Libyan soldiers killed in Benghazi violence

BENGHAZI, Libya (Reuters) - Six soldiers were killed in clashes between Libyan special forces and armed protesters outside a special forces' base in the eastern city of Benghazi, an military official said on Saturday.

Residents in the area said heavy gunfire and explosions were heard during the fighting and hours earlier a group of men had forced their way into a different army compound to steal weapons.

"The clashes lasted from 2:00 a.m. (8 p.m. EDT on Friday) until 6:00 a.m. but are over now," Colonel Mohammed Sharif, of the special forces in Benghazi, told Reuters.

It was not immediately clear who the protesters were and if any had been killed.

Last week at least 31 people were killed and 100 injured in clashes between armed protesters, eventually backed by special forces, and a militia in the city.

The protesters had been demanding the disbanding of militias, and clashed with members of the Libya Shield brigade, which fought to oust former leader Muammar Gaddafi and now says it is aligned with the defense ministry.

(Reporting by Feras Bosalum; Writing by Marie-Louise Gumuchian; Editing by Louise Ireland)

Source: http://news.yahoo.com/five-libyan-soldiers-killed-benghazi-violence-073434911.html

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Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors, study suggests

June 15, 2013 ? A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

The findings, presented June 15, 2013, at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction.

"We found bazedoxifene binds to the estrogen receptor and interferes with its activity, but the surprising thing we then found was that it also degrades the receptor; it gets rid of it," said senior author Donald McDonnell, PhD, chair of Duke's Department of Pharmacology and Cancer Biology.

In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer. Currently, if breast cancer cells develop resistance to these therapies, patients are usually treated with toxic chemotherapy agents that have significant side effects.

Bazedoxifene is a pill that, like tamoxifen, belongs to a class of drugs known as specific estrogen receptor modulators (SERMs). These drugs are distinguished by their ability to behave like estrogen in some tissues, while significantly blocking estrogen action in other tissues. But unlike tamoxifen, bazedoxifene has some of the properties of a newer group of drugs, known as selective estrogen receptor degraders, or SERDs, which can target the estrogen receptor for destruction.

"Because the drug is removing the estrogen receptor as a target by degradation, it is less likely the cancer cell can develop a resistance mechanism because you are removing the target," said lead author Suzanne Wardell, PhD, a research scientist working in McDonnell's lab.

Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.

"We discovered that the estrogen receptor is still a good target, even after it resistance to tamoxifen has developed," he said.

The investigators tested a variety of breast cancer cell types, including tamoxifen-sensitive cells that are resistant to the drug lapatinib, another targeted therapy that is used to treat patients with advanced breast cancer whose tumors contain the mutant HER2 gene. These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance. In this cell type, bazedoxifene also potently inhibited cell growth.

Paradoxically, in bone tissue, bazedoxifene mimics the action of estrogen, helping protect it from destruction. Because bazedoxifene has already undergone safety and efficacy studies as a treatment for osteoporosis, it may be a viable near-term option for patients with advanced breast cancer whose tumors have become resistant to other treatment options, Wardell reported. In clinical trials, the most often reported side effect was hot flashes in the bazedoxifene treatment groups.

The study was funded by a research grant from Pfizer Pharmaceuticals, maker of bazedoxifene.

In addition to Wardell and McDonnell, Erik Nelson and Christina Chao of the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, contributed to the research.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/xbLzKGQubP8/130615152341.htm

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Google launches Internet-beaming balloons

CHRISTCHURCH, New Zealand (AP) ? Wrinkled and skinny at first, the translucent, jellyfish-shaped balloons that Google released this week from a frozen field in the heart of New Zealand's South Island hardened into shiny pumpkins as they rose into the blue winter skies above Lake Tekapo, passing the first big test of a lofty goal to get the entire planet online.

It was the culmination of 18 months' work on what Google calls Project Loon, in recognition of how wacky the idea may sound. Developed in the secretive X lab that came up with a driverless car and web-surfing eyeglasses, the flimsy helium-filled inflatables beam the Internet down to earth as they sail past on the wind.

Still in their experimental stage, the balloons were the first of thousands that Google's leaders eventually hope to launch 20 kilometers (12 miles) into the stratosphere in order to bridge the gaping digital divide between the world's 4.8 billion unwired people and their 2.2 billion plugged-in counterparts.

If successful, the technology might allow countries to leapfrog the expense of laying fiber cable, dramatically increasing Internet usage in places such as Africa and Southeast Asia.

"It's a huge moonshot. A really big goal to go after," said project leader Mike Cassidy. "The power of the Internet is probably one of the most transformative technologies of our time."

The first person to get Google Balloon Internet access this week was Charles Nimmo, a farmer and entrepreneur in the small town of Leeston. He found the experience a little bemusing after he was one of 50 locals who signed up to be a tester for a project that was so secret, no one would explain to them what was happening. Technicians came to the volunteers' homes and attached to the outside walls bright red receivers the size of basketballs and resembling giant Google map pins.

Nimmo got the Internet for about 15 minutes before the balloon transmitting it sailed on past. His first stop on the Web was to check out the weather because he wanted to find out if it was an optimal time for "crutching" his sheep, a term he explained to the technicians refers to removing the wool around sheep's rear ends.

Nimmo is among the many rural folk, even in developed countries, that can't get broadband access. After ditching his dial-up four years ago in favor of satellite Internet service, he's found himself stuck with bills that sometimes exceed $1,000 in a single month.

"It's been weird," Nimmo said of the Google Balloon Internet experience. "But it's been exciting to be part of something new."

While the concept is new, people have used balloons for communication, transportation and entertainment for centuries. In recent years, the military and aeronautical researchers have used tethered balloons to beam Internet signals back to bases on earth.

Google's balloons fly free and out of eyesight, scavenging power from card table-sized solar panels that dangle below and gather enough charge in four hours to power them for a day as the balloons sail around the globe on the prevailing winds. Far below, ground stations with Internet capabilities about 100 kilometers (60 miles) apart bounce signals up to the balloons.

The signals would hop forward, from one balloon to the next, along a backbone of up to five balloons.

Each balloon would provide Internet service for an area twice the size of New York City, about 1,250 square kilometers (780 square miles), and terrain is not a challenge. They could stream Internet into Afghanistan's steep and winding Khyber Pass or Yaounde, the capital of Cameroon, a country where the World Bank estimates four out of every 100 people are online.

There are plenty of catches, including a requirement that anyone using Google Balloon Internet would need a receiver plugged into their computer in order to receive the signal. Google is not talking costs at this point, although they're striving to make both the balloons and receivers as inexpensive as possible, dramatically less than laying cables.

The signals travel in the unlicensed spectrum, which means Google doesn't have to go through the onerous regulatory processes required for Internet providers using wireless communications networks or satellites. In New Zealand, the company worked with the Civil Aviation Authority on the trial. Google chose the country in part because of its remoteness. Cassidy said in the next phase of the trial they hope to get up to 300 balloons forming a ring on the 40th parallel south from New Zealand through Australia, Chile, Uruguay, Paraguay and Argentina.

Christchurch was a symbolic launch site because some residents were cut off from online information for weeks following a 2011 earthquake that killed 185 people. Google believes balloon access could help places suffering natural disasters get quickly back online. Tania Gilchrist, a resident who signed up for the Google trial, feels lucky she lost her power for only about 10 hours on the day of the quake.

"After the initial upheaval, the Internet really came into play," she said. "It was how people coordinated relief efforts and let people know how to get in touch with agencies. It was really, really effective and it wasn't necessarily driven by the authorities."

At Google's mission control in Christchurch this week, a team of jet lagged engineers working at eight large laptops used wind data from the National Oceanic and Atmospheric Administration to maneuver the balloons over snowy peaks, identifying the wind layer with the desired speed and direction and then adjusting balloons' altitudes so they floated in that layer.

"It's a very fundamentally democratic thing that what links everyone together is the sky and the winds," said Richard DeVaul, an MIT-trained scientist who founded Project Loon and helped develop Google Glass, hidden camera-equipped eyeglasses with a tiny computer display that responds to voice commands.

DeVaul initially thought their biggest challenge would be establishing the radio links from earth to sky, but in the end, one of the most complex parts was hand building strong, light, durable balloons that could handle temperature and pressure swings in the stratosphere.

Google engineers studied balloon science from NASA, the Defense Department and the Jet Propulsion Lab to design their own airships made of plastic films similar to grocery bags. Hundreds have been built so far.

He said they wouldn't interfere with aircraft because they fly well below satellites and twice as high as airplanes, and they downplayed concerns about surveillance, emphasizing that they would not carry cameras or any other extraneous equipment.

The balloons would be guided to collection points and replaced periodically. In cases when they failed, a parachute would deploy.

While there had been rumors, until now Google had refused to confirm the project. But there have been hints: In April, Google's executive chairman tweeted "For every person online, there are two who are not. By the end of the decade, everyone on Earth will be connected," prompting a flurry of speculative reports.

And international aid groups have been pushing for more connectivity for more than a decade.

In pilot projects, African farmers solved disease outbreaks after searching the Web, while in Bangladesh "online schools" bring teachers from Dhaka to children in remote classrooms through large screens and video conferencing.

Many experts said the project has the potential to fast-forward developing nations into the digital age, possibly impacting far more people than the Google X lab's first two projects: The glasses and a fleet of self-driving cars that have already logged hundreds of thousands of accident-free miles.

"Whole segments of the population would reap enormous benefits, from social inclusion to educational and economic opportunities," said DePauw University media studies professor Kevin Howley.

Temple University communications professor Patrick Murphy warned of mixed consequences, pointing to China and Brazil where Internet service increased democratic principles, prompting social movements and uprisings, but also a surge in consumerism that has resulted in environmental and health problems.

"The nutritional and medical information, farming techniques, democratic principles those are the wonderful parts of it," he said. "But you also have everyone wanting to drive a car, eat a steak, drink a Coke."

As the world's largest advertising network, Google itself stands to expand its own empire by bringing Internet to the masses: More users means more potential Google searchers, which in turn give the company more chances to display their lucrative ads.

Richard Bennett, a fellow with the nonprofit Information Technology and Innovation Foundation, was skeptical, noting that cell phones are being used far more in developing countries.

"I'm really glad that Google is doing this kind of speculative research," he said. "But it remains to be seen how practical any of these things are."

Ken Murdoch, a chief information officer for the nonprofit Save the Children, said the service would be "a tremendous key enabler" during natural disasters and humanitarian crises, when infrastructure can be nonexistent or paralyzed.

"The potential of a system that can restore connectivity within hours of a crisis hitting is tremendously exciting," agreed Imogen Wall at the United Nations Office for the Coordination of Humanitarian Affairs, although she warned that the service must be robust. "If the service fails in a crisis, then lives are lost."

In Christchurch this week, the balloons were invisible in the sky except for an occasional glint, but people could see them if they happened to be in the remote countryside where they were launched or through binoculars, if they knew where to look.

Before heading to New Zealand, Google spent a few months secretly launching between two and five flights a week in California's central valley, prompting what Google's scientists said were a handful of unusual reports on local media.

"We were chasing balloons around from trucks on the ground," said DeVaul, "and people were calling in reports about UFOs."

___

Mendoza reported from Mountain View, Calif. Follow Martha Mendoza at http://twitter.com/mendozamartha.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-06-15-Google%20Internet%20Balloon/id-8688b2e5ecaa4a56bddb704f1a32299d

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China newspaper: Snowden could be useful to China

BEIJING (AP) ? A popular Communist Party-backed newspaper is urging China's leadership to get more information from former defense contractor Edward Snowden rather than send him back to the U.S., because his revelations about secret U.S. surveillance programs concern China's national interest.

The Global Times newspaper said in an editorial Friday that the Chinese government should not only consider Beijing's relations with the United States but also domestic public opinion, which the paper says would be unhappy if Snowden were sent back.

The Chinese paper known for nationalist views says Snowden could offer intelligence that can help China update its understanding of cyberspace.

Snowden alleged in an interview with a Hong Kong newspaper that the U.S. National Security Agency's 61,000 hacking targets around the world include hundreds in Hong Kong and mainland China.

Source: http://news.yahoo.com/china-newspaper-snowden-could-useful-china-051045837.html

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Photos: Big win for Spurs in Game 3 of NBA Finals

by Kens5.com Staff

khou.com

Posted on June 12, 2013 at 9:21 AM

Gary Neal and Danny Green listened to their coach and kept on shooting. Shaking off a humiliating blowout for the biggest game in San Antonio since 2007, the Spurs kept giving LeBron James fits and ran away with a 113-77 victory Tuesday night.

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Source: http://www.khou.com/news/slideshows/Photos-Big-win-for-Spurs-in-Game-3-of-NBA--211192711.html

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Bryan Stow Goes Home...Because His Insurance Ran Out: LAist

It's been a little over two years since Giants fan Bryan Stow was beat within an inch of his life at the Dodgers' Opening Day game in 2011. It sounds like good news?and Stow's family says they're happy he's back at home?but the circumstances are bittersweet.

Stow's family says that insurance is no longer paying for his rehab at the Centre for Neuroskills, a 24-hour rehab facility in Bakersfield that's about 4 hours from his home in the Bay Area. They call this latest development a "big setback." Stow's family writes on his website that although he has come a long, long way from being on death's door, he still has a ways to go, "Let us clarify something very important -Bryan could have benefited greatly by staying at CNS longer. We are so glad to have him home, but as prepared as we thought we were, it was a difficult transition."

Stow needs 24 hour nursing care, but insurance isn't covering it and his family caring for him struggle to do it alone?administering his medical care, scheduling his appointments, feeding him. So they've hired caregivers out-of-pocket to help Stow get up, shower, get dressed and get tucked into bed.

Stow has come a long way, but he still has serious medical issues and he's definitely not the "old Bryan." They write that spending every day with him they notice all the little things in his life that make it so difficult: "The memory problems, the use of words that do not belong, the pain he is in and the stiffness in his body that prevents him from being able to do things on his own."

Still, the family thanked the public for its support and created a sort of welcome home video:

Louie Sanchez and Marvin Norwood of San Bernardino County are facing charges of mayhem, assault and battery in the attack on Stow. The family is suing the Los Angeles Dodgers claiming that lax security allowed the attack to happen. Stow's attorney's say his medical bills could add up to over $50 million over the course of his life.

Related:
One Year Later: Bryan Stow's Family Reflects on Life Since the Dodgers' Last Opening Day
Bryan Stow Writes His Name, Family Rejoices
Bryan Stow Goes Outside, Says 'It's Magical'
Bryan Stow's Medical Care Costs to Exceed $50 Million

Source: http://laist.com/2013/06/13/bryan_stow_goes_homebecause_his_ins.php

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Iran?s Presidential Election: Does the Sole Moderate Candidate Stand a Chance?

Early Friday morning Iran?s Supreme Leader, Ayatullah Ali Khamenei launched the elections with a ceremonial display of civic duty. In front of a gathering of select Iranian and foreign media, this, the most recognized man in Iran, whose face adorns everything from billboards to hotel lobbies to shop windows across the country, flourished his ID card to receive his ballot. He pressed his index finger to a pad of indelible ink, wrote the names of his preferred candidates ? city council elections are held in tandem with the presidential vote ? into the blanks, and, to a cicada chorus of clicking camera shutters, dropped the ballots into sealed translucent boxes. Then he paused in front of the microphones set up for the occasion. Foreign governments wanted to sabotage Iran?s elections by encouraging people to stay away from the polls, he said. He had even heard that an American government official did not accept that Iran?s elections were democratic. ?I say, to hell with you.? Then he exhorted his nation to vote, a sign of defiance for those who would undermine Iran.

In the weeks running up to the Iranian election?the first since the still-disputed 2009 election and its explosive aftermath?the country?s leadership has equated voting with patriotism. Khamenei, as the country?s most revered religious leader, has eschewed endorsing a candidate, but time and again he has urged people to the polls. ?A vote for any of these candidates is a vote for the Islamic Republic. It?s a vote of confidence in the system,? he said at a rally on June 4. On June 12, he told the nation that a high turnout on Friday ?would dash the enemies? hopes.?

A low turnout, however, could just as easily undermine the government?s claim that Iran?s Islamic political system?a hybrid theocracy that pairs an elected president with a supreme religious leader who has the final say on all matters, secular and religious?is embraced by the people. There are some 50 million eligible voters in Iran, and while government officials and local media outlets boasted of high turnouts, there is no way to independently verify the numbers going to the polls. In rural areas, rumors spread that those who did not vote would see their subsidies cut. In the capital, however, most government officials linked voting with patriotic duty.

And people responded. By mid-morning polling stations across Tehran were busy. Voters waited in line patiently, more resigned than animated. Some had not even chosen their candidates by the time they picked up their ballots. ?I have not yet decided,? said teacher Ghazia Moussavi, wrapped in the voluminous black chador of the extremely religious. ?I will vote for whoever follows our Leader,? she said, meaning Khamenei. In other stations, small groups huddled together around their ballots, weighing their options before committing their collective decision to paper.

Six candidates are in the running, hand selected by Iran?s 12-person Guardian Council. The council, led by Khamenei, rejected hundreds of would-be candidates, including former president Hashemi Rafsanjani, who served two presidential terms from 1989-97. The council never made it clear why Rafsanjani was not eligible to run this time, but most voters seemed resigned to the council?s decision. ?I am sure they had their reasons,? says 22-year-old university student Shayhan Sharif, before obliquely suggesting that Rafsanjani, a popular moderate, might have been deemed too much a threat for a leadership that has taken a conservative turn over the past eight years.

Of the six candidates, only one, Hassan Rowhani, is considered a moderate. The rest are conservatives, including the two front-runners, Iran?s chief nuclear negotiator Saeed Jalili and Mohammad-Baqer Qalibaf, Tehran?s current mayor. At polling stations conservative voters seemed equally divided between Qalibaf and Jalili, raising the possibility of a split vote and raising Rowhani?s chances. (If no candidate gets a majority, the vote will go to a runoff next week.)

But Rowhani faces a far more powerful competitor: voter apathy. Iran?s educated urban youth are still smarting from the fallout from the 2009 election, when their preferred candidate, the charismatic reformist Mir-Hossein Moussavi, lost to incumbent Mahmud Ahmadinejad. Many suspected fraud and millions took to the streets, only to face a brutal crackdown that saw scores killed and thousands detained and beaten. Four years on, many members of Moussavi?s so-called ?green movement? say they will register their protest by not voting. ?Why should I vote?? says 26-year old civil engineer Arash, who asked to go by one name given the sensitivity of his statements. ?After what happened in 2009, I see no reason to trust the system. It is my duty for freedom to not vote in a semi-dictatorship. My vote will give it false legitimacy. This is not a democracy, so there is no point in voting.?

This is the kind of thinking that has kept Vandad Ahmadian, a 32-year-old cinematographer who volunteers for the Rowhani campaign, up at night. For the past two weeks he has stalked former Moussavi voters at birthday parties and restaurants and family gatherings to convince them to vote. ?All these people who don?t want to vote, they are Rowhani?s natural constituency,? he says. If they don?t vote, it would mean that the conservatives win. ?So we are telling them, don?t make a protest by not voting, make your protest by voting for Rowhani.? Iranians may argue whether this election is legitimate or not, but in the end their future still depends on the outcome, says Ahmadian. ?It?s still better to make a choice, rather than have one made for you.?

Source: http://news.yahoo.com/iran-presidential-election-does-sole-moderate-candidate-stand-173951698.html

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Supreme Court Gene Ruling Benefits Biotech, Breast Cancer Research (Voice Of America)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/312608642?client_source=feed&format=rss

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New MacBook Air uses screaming fast PCIe SSD

The new Mac Pro isn't the only new Mac model with PCIe-based Solid State Drive storage. The new MacBook Air, which began shipping this week as soon as it was introduced on stage at WWDC, also uses the technology, according to Ben Lovejoy at 9to5Mac.

Previous MacBook Air models - and all other Macs - have used Serial ATA (SATA) for their main storage. The new MacBook Air is the first shipping Mac model to use PCIe as its primary storage interface instead.

SATA 3.0 transfer speeds top out at 600 megabytes per second, but MacBidoulle benchmarked write speeds of more than 668 MB/s, with read speeds of more than 729 MB/s. And even with that, the PCIe 2.0 2x interface that the MacBook Air uses isn't the bottleneck - it can work at up to 1 gigabyte per second downstream and upstream. As faster SSDs become available, you can expect to see even greater performance.

If you have a Mac Pro (not the shiny and new one, the old and busted big box), you can drop in a PCIe SSD card from OWC and others.

Impressive performance for Apple's lightest weight laptop, and an early indication of what we can expect down the road as more Mac models adopt this new technology.

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/62LogVFMXC8/story01.htm

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GoPro Software Update Hands-On: Easier Sharing, Awesomer Videos

GoPro, the Q-Tips of action cameras, recognized a problem. People are shooting tons of footage with their cameras, but then letting it languish away on a dusty old hard drive, unseen and unedited. The California company is hoping to help correct that with a new mobile apps and desktop editing software.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/4RuXVajA7PQ/gopro-software-update-hands-on-easier-sharing-awesome-512879804

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