Sunday, June 16, 2013

Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors, study suggests

June 15, 2013 ? A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

The findings, presented June 15, 2013, at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction.

"We found bazedoxifene binds to the estrogen receptor and interferes with its activity, but the surprising thing we then found was that it also degrades the receptor; it gets rid of it," said senior author Donald McDonnell, PhD, chair of Duke's Department of Pharmacology and Cancer Biology.

In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer. Currently, if breast cancer cells develop resistance to these therapies, patients are usually treated with toxic chemotherapy agents that have significant side effects.

Bazedoxifene is a pill that, like tamoxifen, belongs to a class of drugs known as specific estrogen receptor modulators (SERMs). These drugs are distinguished by their ability to behave like estrogen in some tissues, while significantly blocking estrogen action in other tissues. But unlike tamoxifen, bazedoxifene has some of the properties of a newer group of drugs, known as selective estrogen receptor degraders, or SERDs, which can target the estrogen receptor for destruction.

"Because the drug is removing the estrogen receptor as a target by degradation, it is less likely the cancer cell can develop a resistance mechanism because you are removing the target," said lead author Suzanne Wardell, PhD, a research scientist working in McDonnell's lab.

Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.

"We discovered that the estrogen receptor is still a good target, even after it resistance to tamoxifen has developed," he said.

The investigators tested a variety of breast cancer cell types, including tamoxifen-sensitive cells that are resistant to the drug lapatinib, another targeted therapy that is used to treat patients with advanced breast cancer whose tumors contain the mutant HER2 gene. These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance. In this cell type, bazedoxifene also potently inhibited cell growth.

Paradoxically, in bone tissue, bazedoxifene mimics the action of estrogen, helping protect it from destruction. Because bazedoxifene has already undergone safety and efficacy studies as a treatment for osteoporosis, it may be a viable near-term option for patients with advanced breast cancer whose tumors have become resistant to other treatment options, Wardell reported. In clinical trials, the most often reported side effect was hot flashes in the bazedoxifene treatment groups.

The study was funded by a research grant from Pfizer Pharmaceuticals, maker of bazedoxifene.

In addition to Wardell and McDonnell, Erik Nelson and Christina Chao of the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, contributed to the research.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/xbLzKGQubP8/130615152341.htm

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Google launches Internet-beaming balloons

(AP) ? Wrinkled and skinny at first, the translucent, jellyfish-shaped balloons that Google released this week from a frozen field in the heart of New Zealand's South Island hardened into shiny pumpkins as they rose into the blue winter skies above Lake Tekapo, passing the first big test of a lofty goal to get the entire planet online.

It was the culmination of 18 months' work on what Google calls Project Loon, in recognition of how wacky the idea may sound. Developed in the secretive X lab that came up with a driverless car and web-surfing eyeglasses, the flimsy helium-filled inflatables beam the Internet down to earth as they sail past on the wind.

Still in their experimental stage, the balloons were the first of thousands that Google's leaders eventually hope to launch 20 kilometers (12 miles) into the stratosphere in order to bridge the gaping digital divide between the world's 4.8 billion unwired people and their 2.2 billion plugged-in counterparts.

If successful, the technology might allow countries to leapfrog the expense of laying fiber cable, dramatically increasing Internet usage in places such as Africa and Southeast Asia.

"It's a huge moonshot. A really big goal to go after," said project leader Mike Cassidy. "The power of the Internet is probably one of the most transformative technologies of our time."

The first person to get Google Balloon Internet access this week was Charles Nimmo, a farmer and entrepreneur in the small town of Leeston. He found the experience a little bemusing after he was one of 50 locals who signed up to be a tester for a project that was so secret, no one would explain to them what was happening. Technicians came to the volunteers' homes and attached to the outside walls bright red receivers the size of basketballs and resembling giant Google map pins.

Nimmo got the Internet for about 15 minutes before the balloon transmitting it sailed on past. His first stop on the Web was to check out the weather because he wanted to find out if it was an optimal time for "crutching" his sheep, a term he explained to the technicians refers to removing the wool around sheep's rear ends.

Nimmo is among the many rural folk, even in developed countries, that can't get broadband access. After ditching his dial-up four years ago in favor of satellite Internet service, he's found himself stuck with bills that sometimes exceed $1,000 in a single month.

"It's been weird," Nimmo said of the Google Balloon Internet experience. "But it's been exciting to be part of something new."

While the concept is new, people have used balloons for communication, transportation and entertainment for centuries. In recent years, the military and aeronautical researchers have used tethered balloons to beam Internet signals back to bases on earth.

Google's balloons fly free and out of eyesight, scavenging power from card table-sized solar panels that dangle below and gather enough charge in four hours to power them for a day as the balloons sail around the globe on the prevailing winds. Far below, ground stations with Internet capabilities about 100 kilometers (60 miles) apart bounce signals up to the balloons.

The signals would hop forward, from one balloon to the next, along a backbone of up to five balloons.

Each balloon would provide Internet service for an area twice the size of New York City, about 1,250 square kilometers (780 square miles), and terrain is not a challenge. They could stream Internet into Afghanistan's steep and winding Khyber Pass or Yaounde, the capital of Cameroon, a country where the World Bank estimates four out of every 100 people are online.

There are plenty of catches, including a requirement that anyone using Google Balloon Internet would need a receiver plugged into their computer in order to receive the signal. Google is not talking costs at this point, although they're striving to make both the balloons and receivers as inexpensive as possible, dramatically less than laying cables.

The signals travel in the unlicensed spectrum, which means Google doesn't have to go through the onerous regulatory processes required for Internet providers using wireless communications networks or satellites. In New Zealand, the company worked with the Civil Aviation Authority on the trial. Google chose the country in part because of its remoteness. Cassidy said in the next phase of the trial they hope to get up to 300 balloons forming a ring on the 40th parallel south from New Zealand through Australia, Chile, Uruguay, Paraguay and Argentina.

Christchurch was a symbolic launch site because some residents were cut off from online information for weeks following a 2011 earthquake that killed 185 people. Google believes balloon access could help places suffering natural disasters get quickly back online. Tania Gilchrist, a resident who signed up for the Google trial, feels lucky she lost her power for only about 10 hours on the day of the quake.

"After the initial upheaval, the Internet really came into play," she said. "It was how people coordinated relief efforts and let people know how to get in touch with agencies. It was really, really effective and it wasn't necessarily driven by the authorities."

At Google's mission control in Christchurch this week, a team of jet lagged engineers working at eight large laptops used wind data from the National Oceanic and Atmospheric Administration to maneuver the balloons over snowy peaks, identifying the wind layer with the desired speed and direction and then adjusting balloons' altitudes so they floated in that layer.

"It's a very fundamentally democratic thing that what links everyone together is the sky and the winds," said Richard DeVaul, an MIT-trained scientist who founded Project Loon and helped develop Google Glass, hidden camera-equipped eyeglasses with a tiny computer display that responds to voice commands.

DeVaul initially thought their biggest challenge would be establishing the radio links from earth to sky, but in the end, one of the most complex parts was hand building strong, light, durable balloons that could handle temperature and pressure swings in the stratosphere.

Google engineers studied balloon science from NASA, the Defense Department and the Jet Propulsion Lab to design their own airships made of plastic films similar to grocery bags. Hundreds have been built so far.

He said they wouldn't interfere with aircraft because they fly well below satellites and twice as high as airplanes, and they downplayed concerns about surveillance, emphasizing that they would not carry cameras or any other extraneous equipment.

The balloons would be guided to collection points and replaced periodically. In cases when they failed, a parachute would deploy.

While there had been rumors, until now Google had refused to confirm the project. But there have been hints: In April, Google's executive chairman tweeted "For every person online, there are two who are not. By the end of the decade, everyone on Earth will be connected," prompting a flurry of speculative reports.

And international aid groups have been pushing for more connectivity for more than a decade.

In pilot projects, African farmers solved disease outbreaks after searching the Web, while in Bangladesh "online schools" bring teachers from Dhaka to children in remote classrooms through large screens and video conferencing.

Many experts said the project has the potential to fast-forward developing nations into the digital age, possibly impacting far more people than the Google X lab's first two projects: The glasses and a fleet of self-driving cars that have already logged hundreds of thousands of accident-free miles.

"Whole segments of the population would reap enormous benefits, from social inclusion to educational and economic opportunities," said DePauw University media studies professor Kevin Howley.

Temple University communications professor Patrick Murphy warned of mixed consequences, pointing to China and Brazil where Internet service increased democratic principles, prompting social movements and uprisings, but also a surge in consumerism that has resulted in environmental and health problems.

"The nutritional and medical information, farming techniques, democratic principles those are the wonderful parts of it," he said. "But you also have everyone wanting to drive a car, eat a steak, drink a Coke."

As the world's largest advertising network, Google itself stands to expand its own empire by bringing Internet to the masses: More users means more potential Google searchers, which in turn give the company more chances to display their lucrative ads.

Richard Bennett, a fellow with the nonprofit Information Technology and Innovation Foundation, was skeptical, noting that cell phones are being used far more in developing countries.

"I'm really glad that Google is doing this kind of speculative research," he said. "But it remains to be seen how practical any of these things are."

Ken Murdoch, a chief information officer for the nonprofit Save the Children, said the service would be "a tremendous key enabler" during natural disasters and humanitarian crises, when infrastructure can be nonexistent or paralyzed.

"The potential of a system that can restore connectivity within hours of a crisis hitting is tremendously exciting," agreed Imogen Wall at the United Nations Office for the Coordination of Humanitarian Affairs, although she warned that the service must be robust. "If the service fails in a crisis, then lives are lost."

In Christchurch this week, the balloons were invisible in the sky except for an occasional glint, but people could see them if they happened to be in the remote countryside where they were launched or through binoculars, if they knew where to look.

Before heading to New Zealand, Google spent a few months secretly launching between two and five flights a week in California's central valley, prompting what Google's scientists said were a handful of unusual reports on local media.

"We were chasing balloons around from trucks on the ground," said DeVaul, "and people were calling in reports about UFOs."

___

Mendoza reported from Mountain View, Calif. Follow Martha Mendoza at http://twitter.com/mendozamartha.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-06-15-Google%20Internet%20Balloon/id-8688b2e5ecaa4a56bddb704f1a32299d

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Saturday, June 15, 2013

China newspaper: Snowden could be useful to China

BEIJING (AP) ? A popular Communist Party-backed newspaper is urging China's leadership to get more information from former defense contractor Edward Snowden rather than send him back to the U.S., because his revelations about secret U.S. surveillance programs concern China's national interest.

The Global Times newspaper said in an editorial Friday that the Chinese government should not only consider Beijing's relations with the United States but also domestic public opinion, which the paper says would be unhappy if Snowden were sent back.

The Chinese paper known for nationalist views says Snowden could offer intelligence that can help China update its understanding of cyberspace.

Snowden alleged in an interview with a Hong Kong newspaper that the U.S. National Security Agency's 61,000 hacking targets around the world include hundreds in Hong Kong and mainland China.

Source: http://news.yahoo.com/china-newspaper-snowden-could-useful-china-051045837.html

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Friday, June 14, 2013

Photos: Big win for Spurs in Game 3 of NBA Finals

by Kens5.com Staff

khou.com

Posted on June 12, 2013 at 9:21 AM

Gary Neal and Danny Green listened to their coach and kept on shooting. Shaking off a humiliating blowout for the biggest game in San Antonio since 2007, the Spurs kept giving LeBron James fits and ran away with a 113-77 victory Tuesday night.

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Source: http://www.khou.com/news/slideshows/Photos-Big-win-for-Spurs-in-Game-3-of-NBA--211192711.html

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Bryan Stow Goes Home...Because His Insurance Ran Out: LAist

It's been a little over two years since Giants fan Bryan Stow was beat within an inch of his life at the Dodgers' Opening Day game in 2011. It sounds like good news?and Stow's family says they're happy he's back at home?but the circumstances are bittersweet.

Stow's family says that insurance is no longer paying for his rehab at the Centre for Neuroskills, a 24-hour rehab facility in Bakersfield that's about 4 hours from his home in the Bay Area. They call this latest development a "big setback." Stow's family writes on his website that although he has come a long, long way from being on death's door, he still has a ways to go, "Let us clarify something very important -Bryan could have benefited greatly by staying at CNS longer. We are so glad to have him home, but as prepared as we thought we were, it was a difficult transition."

Stow needs 24 hour nursing care, but insurance isn't covering it and his family caring for him struggle to do it alone?administering his medical care, scheduling his appointments, feeding him. So they've hired caregivers out-of-pocket to help Stow get up, shower, get dressed and get tucked into bed.

Stow has come a long way, but he still has serious medical issues and he's definitely not the "old Bryan." They write that spending every day with him they notice all the little things in his life that make it so difficult: "The memory problems, the use of words that do not belong, the pain he is in and the stiffness in his body that prevents him from being able to do things on his own."

Still, the family thanked the public for its support and created a sort of welcome home video:

Louie Sanchez and Marvin Norwood of San Bernardino County are facing charges of mayhem, assault and battery in the attack on Stow. The family is suing the Los Angeles Dodgers claiming that lax security allowed the attack to happen. Stow's attorney's say his medical bills could add up to over $50 million over the course of his life.

Related:
One Year Later: Bryan Stow's Family Reflects on Life Since the Dodgers' Last Opening Day
Bryan Stow Writes His Name, Family Rejoices
Bryan Stow Goes Outside, Says 'It's Magical'
Bryan Stow's Medical Care Costs to Exceed $50 Million

Source: http://laist.com/2013/06/13/bryan_stow_goes_homebecause_his_ins.php

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Iran?s Presidential Election: Does the Sole Moderate Candidate Stand a Chance?

Early Friday morning Iran?s Supreme Leader, Ayatullah Ali Khamenei launched the elections with a ceremonial display of civic duty. In front of a gathering of select Iranian and foreign media, this, the most recognized man in Iran, whose face adorns everything from billboards to hotel lobbies to shop windows across the country, flourished his ID card to receive his ballot. He pressed his index finger to a pad of indelible ink, wrote the names of his preferred candidates ? city council elections are held in tandem with the presidential vote ? into the blanks, and, to a cicada chorus of clicking camera shutters, dropped the ballots into sealed translucent boxes. Then he paused in front of the microphones set up for the occasion. Foreign governments wanted to sabotage Iran?s elections by encouraging people to stay away from the polls, he said. He had even heard that an American government official did not accept that Iran?s elections were democratic. ?I say, to hell with you.? Then he exhorted his nation to vote, a sign of defiance for those who would undermine Iran.

In the weeks running up to the Iranian election?the first since the still-disputed 2009 election and its explosive aftermath?the country?s leadership has equated voting with patriotism. Khamenei, as the country?s most revered religious leader, has eschewed endorsing a candidate, but time and again he has urged people to the polls. ?A vote for any of these candidates is a vote for the Islamic Republic. It?s a vote of confidence in the system,? he said at a rally on June 4. On June 12, he told the nation that a high turnout on Friday ?would dash the enemies? hopes.?

A low turnout, however, could just as easily undermine the government?s claim that Iran?s Islamic political system?a hybrid theocracy that pairs an elected president with a supreme religious leader who has the final say on all matters, secular and religious?is embraced by the people. There are some 50 million eligible voters in Iran, and while government officials and local media outlets boasted of high turnouts, there is no way to independently verify the numbers going to the polls. In rural areas, rumors spread that those who did not vote would see their subsidies cut. In the capital, however, most government officials linked voting with patriotic duty.

And people responded. By mid-morning polling stations across Tehran were busy. Voters waited in line patiently, more resigned than animated. Some had not even chosen their candidates by the time they picked up their ballots. ?I have not yet decided,? said teacher Ghazia Moussavi, wrapped in the voluminous black chador of the extremely religious. ?I will vote for whoever follows our Leader,? she said, meaning Khamenei. In other stations, small groups huddled together around their ballots, weighing their options before committing their collective decision to paper.

Six candidates are in the running, hand selected by Iran?s 12-person Guardian Council. The council, led by Khamenei, rejected hundreds of would-be candidates, including former president Hashemi Rafsanjani, who served two presidential terms from 1989-97. The council never made it clear why Rafsanjani was not eligible to run this time, but most voters seemed resigned to the council?s decision. ?I am sure they had their reasons,? says 22-year-old university student Shayhan Sharif, before obliquely suggesting that Rafsanjani, a popular moderate, might have been deemed too much a threat for a leadership that has taken a conservative turn over the past eight years.

Of the six candidates, only one, Hassan Rowhani, is considered a moderate. The rest are conservatives, including the two front-runners, Iran?s chief nuclear negotiator Saeed Jalili and Mohammad-Baqer Qalibaf, Tehran?s current mayor. At polling stations conservative voters seemed equally divided between Qalibaf and Jalili, raising the possibility of a split vote and raising Rowhani?s chances. (If no candidate gets a majority, the vote will go to a runoff next week.)

But Rowhani faces a far more powerful competitor: voter apathy. Iran?s educated urban youth are still smarting from the fallout from the 2009 election, when their preferred candidate, the charismatic reformist Mir-Hossein Moussavi, lost to incumbent Mahmud Ahmadinejad. Many suspected fraud and millions took to the streets, only to face a brutal crackdown that saw scores killed and thousands detained and beaten. Four years on, many members of Moussavi?s so-called ?green movement? say they will register their protest by not voting. ?Why should I vote?? says 26-year old civil engineer Arash, who asked to go by one name given the sensitivity of his statements. ?After what happened in 2009, I see no reason to trust the system. It is my duty for freedom to not vote in a semi-dictatorship. My vote will give it false legitimacy. This is not a democracy, so there is no point in voting.?

This is the kind of thinking that has kept Vandad Ahmadian, a 32-year-old cinematographer who volunteers for the Rowhani campaign, up at night. For the past two weeks he has stalked former Moussavi voters at birthday parties and restaurants and family gatherings to convince them to vote. ?All these people who don?t want to vote, they are Rowhani?s natural constituency,? he says. If they don?t vote, it would mean that the conservatives win. ?So we are telling them, don?t make a protest by not voting, make your protest by voting for Rowhani.? Iranians may argue whether this election is legitimate or not, but in the end their future still depends on the outcome, says Ahmadian. ?It?s still better to make a choice, rather than have one made for you.?

Source: http://news.yahoo.com/iran-presidential-election-does-sole-moderate-candidate-stand-173951698.html

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Supreme Court Gene Ruling Benefits Biotech, Breast Cancer Research (Voice Of America)

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